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Structure-activity relationships for unit C pyridyl analogues of the tuberculosis drug bedaquiline
The ATP-synthase inhibitor bedaquiline is effective against drug-resistant tuberculosis but is extremely lipophilic (clogP 7.25) with a very long plasma half-life. Additionally, inhibition of potassium current through the cardiac hERG channel by bedaquiline, is associated with prolongation of the QT...
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| Publicado no: | Bioorg Med Chem |
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| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier Science
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6467542/ https://ncbi.nlm.nih.gov/pubmed/30792104 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2019.02.025 |
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