Structure-activity relationships for unit C pyridyl analogues of the tuberculosis drug bedaquiline

The ATP-synthase inhibitor bedaquiline is effective against drug-resistant tuberculosis but is extremely lipophilic (clogP 7.25) with a very long plasma half-life. Additionally, inhibition of potassium current through the cardiac hERG channel by bedaquiline, is associated with prolongation of the QT...

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Vydáno v:Bioorg Med Chem
Hlavní autoři: Blaser, Adrian, Sutherland, Hamish S., Tong, Amy S.T., Choi, Peter J., Conole, Daniel, Franzblau, Scott G., Cooper, Christopher B., Upton, Anna M., Lotlikar, Manisha, Denny, William A., Palmer, Brian D.
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier Science 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6467542/
https://ncbi.nlm.nih.gov/pubmed/30792104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2019.02.025
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