TBAJ-876, a 3,5-Dialkoxypyridine Analogue of Bedaquiline, Is Active against Mycobacterium abscessus

Lung disease caused by Mycobacterium abscessus is very difficult to cure, and treatment failure rates are high. The antituberculosis drug bedaquiline (BDQ) is used as salvage therapy against this dreadful disease. However, BDQ is highly lipophilic, displays a long terminal half-life, and presents a...

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Foilsithe in:Antimicrob Agents Chemother
Main Authors: Sarathy, Jickky Palmae, Ganapathy, Uday S., Zimmerman, Matthew D., Dartois, Véronique, Gengenbacher, Martin, Dick, Thomas
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 2020
Ábhair:
Experimental Therapeutics
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7179298/
https://ncbi.nlm.nih.gov/pubmed/31964791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02404-19
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