Safety, Tolerability, and Population Pharmacokinetics of Intravenous and Oral Isavuconazonium Sulfate in Pediatric Patients

Isavuconazole, administered as the water-soluble prodrug isavuconazonium sulfate, is a new triazole agent used to treat invasive fungal infections. This phase 1 study evaluated the pharmacokinetics (PK), safety, and tolerability of isavuconazole in 46 immunocompromised pediatric patients, stratified...

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Detaylı Bibliyografya
Yayımlandı:Antimicrob Agents Chemother
Asıl Yazarlar: Arrieta, Antonio C., Neely, Michael, Day, J. Christopher, Rheingold, Susan R., Sue, Paul K., Muller, William J., Danziger-Isakov, Lara A., Chu, Julie, Yildirim, Inci, McComsey, Grace A., Frangoul, Haydar A., Chen, Tempe K., Statler, Victoria A., Steinbach, William J., Yin, Dwight E., Hamed, Kamal, Jones, Mark E., Lademacher, Christopher, Desai, Amit, Micklus, Kelley, Phillips, Desiree Leiva, Kovanda, Laura L., Walsh, Thomas J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2021
Konular:
Clinical Therapeutics
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8284446/
https://ncbi.nlm.nih.gov/pubmed/34031051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00290-21
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