Safety, Tolerability, and Population Pharmacokinetics of Intravenous and Oral Isavuconazonium Sulfate in Pediatric Patients

Isavuconazole, administered as the water-soluble prodrug isavuconazonium sulfate, is a new triazole agent used to treat invasive fungal infections. This phase 1 study evaluated the pharmacokinetics (PK), safety, and tolerability of isavuconazole in 46 immunocompromised pediatric patients, stratified...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Arrieta, Antonio C., Neely, Michael, Day, J. Christopher, Rheingold, Susan R., Sue, Paul K., Muller, William J., Danziger-Isakov, Lara A., Chu, Julie, Yildirim, Inci, McComsey, Grace A., Frangoul, Haydar A., Chen, Tempe K., Statler, Victoria A., Steinbach, William J., Yin, Dwight E., Hamed, Kamal, Jones, Mark E., Lademacher, Christopher, Desai, Amit, Micklus, Kelley, Phillips, Desiree Leiva, Kovanda, Laura L., Walsh, Thomas J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2021
Assuntos:
Clinical Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8284446/
https://ncbi.nlm.nih.gov/pubmed/34031051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00290-21
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