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Two Phase 1, Open‐Label, Mass Balance Studies to Determine the Pharmacokinetics of (14)C‐Labeled Isavuconazonium Sulfate in Healthy Male Volunteers

Isavuconazonium sulfate is the water‐soluble prodrug of the active triazole isavuconazole. Two phase 1 studies were conducted to identify the metabolic profile and mass balance of isavuconazole and BAL8728 (inactive cleavage product). Seven subjects in study 1 (isavuconazole mass balance) received a...

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Bibliografiske detaljer
Udgivet i:Clin Pharmacol Drug Dev
Main Authors: Townsend, Robert, Kato, Kota, Hale, Christine, Kowalski, Donna, Lademacher, Christopher, Yamazaki, Takao, Akhtar, Shahzad, Desai, Amit
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5811773/
https://ncbi.nlm.nih.gov/pubmed/28750160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpdd.376
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