Integrated Polygenic Tool Substantially Enhances Coronary Artery Disease Prediction

BACKGROUND: There is considerable interest in whether genetic data can be used to improve standard cardiovascular disease risk calculators, as the latter are routinely used in clinical practice to manage preventative treatment. METHODS: Using the UK Biobank resource, we developed our own polygenic r...

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Detalhes bibliográficos
Publicado no:Circ Genom Precis Med
Main Authors: Riveros-Mckay, Fernando, Weale, Michael E., Moore, Rachel, Selzam, Saskia, Krapohl, Eva, Sivley, R. Michael, Tarran, William A., Sørensen, Peter, Lachapelle, Alexander S., Griffiths, Jonathan A., Saffari, Ayden, Deanfield, John, Spencer, Chris C.A., Hippisley-Cox, Julia, Hunter, David J., O’Sullivan, Jack W., Ashley, Euan A., Plagnol, Vincent, Donnelly, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2021
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8284388/
https://ncbi.nlm.nih.gov/pubmed/33651632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCGEN.120.003304
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