The Genomic Response to TGF-β1 Dictates Failed Repair and Progression of Fibrotic Disease in the Obstructed Kidney

Tubulointerstitial fibrosis is a common and diagnostic hallmark of a spectrum of chronic renal disorders. While the etiology varies as to the causative nature of the underlying pathology, persistent TGF-β1 signaling drives the relentless progression of renal fibrotic disease. TGF-β1 orchestrates the...

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Detalhes bibliográficos
Publicado no:Front Cell Dev Biol
Main Authors: Higgins, Craig E., Tang, Jiaqi, Higgins, Stephen P., Gifford, Cody C., Mian, Badar M., Jones, David M., Zhang, Wenzheng, Costello, Angelica, Conti, David J., Samarakoon, Rohan, Higgins, Paul J.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Cell and Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8284093/
https://ncbi.nlm.nih.gov/pubmed/34277620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2021.678524
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