Programmed cell death protein-1 (PD-1) protects liver damage by suppressing IFN-γ expression in T cells in infants and neonatal mice

BACKGROUND: Biliary atresia (BA) is a severe cholangiopathy possibly resulting from virus-induced and immune-mediated injury of the biliary system. IFN-γ, secreted from CD4(+) Th1 cells and CD8(+) cytotoxic T cells, is a major mediator of liver pathology. Programmed death protein-1 (PD-1) signaling...

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Gepubliceerd in:BMC Pediatr
Hoofdauteurs: Guo, Xuangjie, Xu, Yiping, Luo, Wei, Fang, Rongli, Cai, Li, Wang, Ping, Zhang, Yuxia, Wen, Zhe, Xu, Yanhui
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2021
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Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8284022/
https://ncbi.nlm.nih.gov/pubmed/34271894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12887-021-02794-x
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