The IFN-γ/PD-L1 axis between T cells and tumor microenvironment: hints for glioma anti-PD-1/PD-L1 therapy

BACKGROUND: PD-L1 is an immune inhibitory receptor ligand that leads to T cell dysfunction and apoptosis by binding to its receptor PD-1, which works in braking inflammatory response and conspiring tumor immune evasion. However, in gliomas, the cause of PD-L1 expression in the tumor microenvironment...

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Detalhes bibliográficos
Publicado no:J Neuroinflammation
Main Authors: Qian, Jiawen, Wang, Chen, Wang, Bo, Yang, Jiao, Wang, Yuedi, Luo, Feifei, Xu, Junying, Zhao, Chujun, Liu, Ronghua, Chu, Yiwei
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6192101/
https://ncbi.nlm.nih.gov/pubmed/30333036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-018-1330-2
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