N6-methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation

N(6)-methyladenosine (m(6)A) on mRNAs mediates different biological processes and its dysregulation contributes to tumorigenesis. How m(6)A dictates its diverse molecular and cellular effects in leukemias remains unknown. We found that YTHDC1 is the essential m(6)A reader in myeloid leukemia from a...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Cancer Cell
Main Authors: Cheng, Yuanming, Xie, Wei, Pickering, Brian F, Chu, Karen L, Savino, Angela M, Yang, Xuejing, Luo, Hanzhi, Nguyen, Diu TT, Mo, Shanlan, Barin, Ersilia, Velleca, Anthony, Rohwetter, Thomas, Patel, Dinshaw J, Jaffrey, Samie R, Kharas, Michael G
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8282764/
https://ncbi.nlm.nih.gov/pubmed/34048709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2021.04.017
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados