High fructose drives the serine synthesis pathway in acute myeloid leukemic cells

A significant increase in dietary fructose consumption has been implicated as a potential driver of cancer. Metabolic adaptation of cancer cells to utilize fructose confers advantages for their malignant growth, but compelling therapeutic targets have not been identified. Here, we show that fructose...

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Vydáno v:Cell Metab
Hlavní autoři: Jeong, Sangmoo, Savino, Angela Maria, Chirayil, Rachel, Barin, Ersilia, Cheng, Yuanming, Park, Sun-Mi, Schurer, Alexandra, Mullarky, Edouard, Cantley, Lewis C., Kharas, Michael G., Keshari, Kayvan R.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8168776/
https://ncbi.nlm.nih.gov/pubmed/33357456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2020.12.005
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