IKZF2 drives leukemia stem cell self-renewal and inhibits myeloid differentiation

Leukemias exhibit a dysregulated developmental program mediated through both genetic and epigenetic mechanisms. Although IKZF2 is expressed in hematopoietic stem cells (HSCs), we found that it is dispensable for mouse and human HSC function. In contrast to its role as a tumor suppressor in hypodiplo...

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Detalhes bibliográficos
Publicado no:Cell Stem Cell
Main Authors: Park, Sun-Mi, Cho, Hyunwoo, Thornton, Angela M., Barlowe, Trevor S., Chou, Timothy, Chhangawala, Sagar, Fairchild, Lauren, Taggart, James, Chow, Arthur, Schurer, Alexandria, Gruet, Antoine, Witkin, Matthew D., Kim, Jun Hyun, Shevach, Ethan M., Krivtsov, Andrei, Armstrong, Scott A., Leslie, Christina, Kharas, Michael G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6602096/
https://ncbi.nlm.nih.gov/pubmed/30472158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2018.10.016
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