IKZF2 drives leukemia stem cell self-renewal and inhibits myeloid differentiation

Leukemias exhibit a dysregulated developmental program mediated through both genetic and epigenetic mechanisms. Although IKZF2 is expressed in hematopoietic stem cells (HSCs), we found that it is dispensable for mouse and human HSC function. In contrast to its role as a tumor suppressor in hypodiplo...

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Pubblicato in:Cell Stem Cell
Autori principali: Park, Sun-Mi, Cho, Hyunwoo, Thornton, Angela M., Barlowe, Trevor S., Chou, Timothy, Chhangawala, Sagar, Fairchild, Lauren, Taggart, James, Chow, Arthur, Schurer, Alexandria, Gruet, Antoine, Witkin, Matthew D., Kim, Jun Hyun, Shevach, Ethan M., Krivtsov, Andrei, Armstrong, Scott A., Leslie, Christina, Kharas, Michael G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6602096/
https://ncbi.nlm.nih.gov/pubmed/30472158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2018.10.016
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