N6-methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation

N(6)-methyladenosine (m(6)A) on mRNAs mediates different biological processes and its dysregulation contributes to tumorigenesis. How m(6)A dictates its diverse molecular and cellular effects in leukemias remains unknown. We found that YTHDC1 is the essential m(6)A reader in myeloid leukemia from a...

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Bibliografski detalji
Izdano u:Cancer Cell
Glavni autori: Cheng, Yuanming, Xie, Wei, Pickering, Brian F, Chu, Karen L, Savino, Angela M, Yang, Xuejing, Luo, Hanzhi, Nguyen, Diu TT, Mo, Shanlan, Barin, Ersilia, Velleca, Anthony, Rohwetter, Thomas, Patel, Dinshaw J, Jaffrey, Samie R, Kharas, Michael G
Format: Artigo
Jezik:Inglês
Izdano: 2021
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8282764/
https://ncbi.nlm.nih.gov/pubmed/34048709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2021.04.017
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