The N(6)-methyladenosine (m(6)A)-forming enzyme METTL3 controls myeloid differentiation of normal and leukemia cells

N(6)-methyladenosine (m(6)A) is an abundant nucleotide modification in mRNA that is required for the differentiation of mouse embryonic stem cells. However, it remains unknown whether m(6)A controls differentiation of normal and/or malignant myeloid hematopoietic cells. Here we show that shRNA-media...

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Pubblicato in:Nat Med
Autori principali: Vu, Ly P., Pickering, Brian F., Cheng, Yuanming, Zaccara, Sara, Nguyen, Diu, Minuesa, Gerard, Chou, Timothy, Chow, Arthur, Saletore, Yogesh, MacKay, Matthew, Schulman, Jessica, Famulare, Christopher, Patel, Minal, Klimek, Virginia M., Garrett-Bakelman, Francine E., Melnick, Ari, Carroll, Martin, Mason, Christopher E., Jaffrey, Samie R., Kharas, Michael G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5677536/
https://ncbi.nlm.nih.gov/pubmed/28920958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4416
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