Mitochondrial mistranslation modulated by metabolic stress causes cardiovascular disease and reduced lifespan

Changes in the rate and fidelity of mitochondrial protein synthesis impact the metabolic and physiological roles of mitochondria. Here we explored how environmental stress in the form of a high‐fat diet modulates mitochondrial translation and affects lifespan in mutant mice with error‐prone (Mrps12(...

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Publicado en:Aging Cell
Main Authors: Richman, Tara R., Ermer, Judith A., Siira, Stefan J., Kuznetsova, Irina, Brosnan, Christopher A., Rossetti, Giulia, Baker, Jessica, Perks, Kara L., Cserne Szappanos, Henrietta, Viola, Helena M., Gray, Nicola, Larance, Mark, Hool, Livia C., Zuryn, Steven, Rackham, Oliver, Filipovska, Aleksandra
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2021
Assuntos:
Original Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8282274/
https://ncbi.nlm.nih.gov/pubmed/34096683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.13408
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