Mitochondrial mistranslation modulated by metabolic stress causes cardiovascular disease and reduced lifespan

Changes in the rate and fidelity of mitochondrial protein synthesis impact the metabolic and physiological roles of mitochondria. Here we explored how environmental stress in the form of a high‐fat diet modulates mitochondrial translation and affects lifespan in mutant mice with error‐prone (Mrps12(...

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Опубликовано в: :Aging Cell
Главные авторы: Richman, Tara R., Ermer, Judith A., Siira, Stefan J., Kuznetsova, Irina, Brosnan, Christopher A., Rossetti, Giulia, Baker, Jessica, Perks, Kara L., Cserne Szappanos, Henrietta, Viola, Helena M., Gray, Nicola, Larance, Mark, Hool, Livia C., Zuryn, Steven, Rackham, Oliver, Filipovska, Aleksandra
Формат: Artigo
Язык:Inglês
Опубликовано: John Wiley and Sons Inc. 2021
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Original Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8282274/
https://ncbi.nlm.nih.gov/pubmed/34096683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.13408
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