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The Genetic and Clinical Significance of Fetal Hemoglobin Expression in Sickle Cell Disease
Sickle cell disease (SCD) is phenotypically heterogeneous. One major genetic modifying factor is the patient's fetal hemoglobin (HbF) level. The latter is determined by the patient's β-globin gene cluster haplotype and cis- and trans-acting single nucleotide polymorphisms (SNPs) at other d...
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| 發表在: | Med Princ Pract |
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| 主要作者: | |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
S. Karger AG
2021
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8280415/ https://ncbi.nlm.nih.gov/pubmed/32892201 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000511342 |
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