A prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes

Successful cell division relies on the timely removal of key cell cycle proteins such as securin. Securin inhibits separase, which cleaves the cohesin rings holding chromosomes together. Securin must be depleted before anaphase to ensure chromosome segregation occurs with anaphase. Here we find that...

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Библиографические подробности
Опубликовано в: :Nat Commun
Главные авторы: Thomas, Christopher, Wetherall, Benjamin, Levasseur, Mark D., Harris, Rebecca J., Kerridge, Scott T., Higgins, Jonathan M. G., Davies, Owen R., Madgwick, Suzanne
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2021
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8280194/
https://ncbi.nlm.nih.gov/pubmed/34262048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24554-2
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