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Prometaphase APC(cdh1) activity prevents non-disjunction in mammalian oocytes

The first female meiotic division (MI) is uniquely prone to chromosome segregation errors through non-disjunction, resulting in trisomies and early pregnancy loss1. Here, we show a fundamental difference in the control of mammalian meiosis which may underlie such susceptibility. It involved a revers...

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Bibliografiska uppgifter
Huvudupphovsmän: Reis, Alexandra, Madgwick, Suzanne, Chang, Heng-Yu, Nabti, Ibtissem, Levasseur, Mark, Jones, Keith T
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2007
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2323444/
https://ncbi.nlm.nih.gov/pubmed/17891138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb1640
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