Phosphorylated tau181 in plasma as a potential biomarker for Alzheimer’s disease in adults with Down syndrome

Plasma tau phosphorylated at threonine 181 (p-tau181) predicts Alzheimer’s disease (AD) pathology with high accuracy in the general population. In this study, we investigated plasma p-tau181 as a biomarker of AD in individuals with Down syndrome (DS). We included 366 adults with DS (240 asymptomatic...

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Vydáno v:Nat Commun
Hlavní autoři: Lleó, Alberto, Zetterberg, Henrik, Pegueroles, Jordi, Karikari, Thomas K., Carmona-Iragui, María, Ashton, Nicholas J., Montal, Victor, Barroeta, Isabel, Lantero-Rodríguez, Juan, Videla, Laura, Altuna, Miren, Benejam, Bessy, Fernandez, Susana, Valldeneu, Silvia, Garzón, Diana, Bejanin, Alexandre, Iulita, Maria Florencia, Camacho, Valle, Medrano-Martorell, Santiago, Belbin, Olivia, Clarimon, Jordi, Lehmann, Sylvain, Alcolea, Daniel, Blesa, Rafael, Blennow, Kaj, Fortea, Juan
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8280160/
https://ncbi.nlm.nih.gov/pubmed/34262030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24319-x
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