Cerebrospinal fluid profile of NPTX2 supports role of Alzheimer’s disease-related inhibitory circuit dysfunction in adults with Down syndrome

BACKGROUND: Alzheimer’s disease (AD) is the major cause of death in adults with Down syndrome (DS). There is an urgent need for objective markers of AD in the DS population to improve early diagnosis and monitor disease progression. NPTX2 has recently emerged as a promising cerebrospinal fluid (CSF)...

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Publicat a:Mol Neurodegener
Autors principals: Belbin, Olivia, Xiao, Mei-Fang, Xu, Desheng, Carmona-Iragui, Maria, Pegueroles, Jordi, Benejam, Bessy, Videla, Laura, Fernández, Susana, Barroeta, Isabel, Nuñez-Llaves, Raúl, Montal, Victor, Vilaplana, Eduard, Altuna, Miren, Clarimón, Jordi, Alcolea, Daniel, Blesa, Rafael, Lleó, Alberto, Worley, Paul F., Fortea, Juan
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2020
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7433053/
https://ncbi.nlm.nih.gov/pubmed/32807227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-020-00398-0
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