Association of Apolipoprotein E ɛ4 Allele With Clinical and Multimodal Biomarker Changes of Alzheimer Disease in Adults With Down Syndrome

IMPORTANCE: Alzheimer disease (AD) is the leading cause of death in individuals with Down syndrome (DS). Previous studies have suggested that the APOE ɛ4 allele plays a role in the risk and age at onset of dementia in DS; however, data on in vivo biomarkers remain scarce. OBJECTIVE: To investigate t...

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Bibliographic Details
Published in:JAMA Neurol
Main Authors: Bejanin, Alexandre, Iulita, Maria Florencia, Vilaplana, Eduard, Carmona-Iragui, Maria, Benejam, Bessy, Videla, Laura, Barroeta, Isabel, Fernandez, Susana, Altuna, Miren, Pegueroles, Jordi, Montal, Victor, Valldeneu, Silvia, Giménez, Sandra, González-Ortiz, Sofía, Muñoz, Laia, Padilla, Concepción, Aranha, Mateus Rozalem, Estellés, Teresa, Illán-Gala, Ignacio, Belbin, Olivia, Camacho, Valle, Wilson, Liam Reese, Annus, Tiina, Osorio, Ricardo S., Videla, Sebastián, Lehmann, Sylvain, Holland, Anthony J., Zetterberg, Henrik, Blennow, Kaj, Alcolea, Daniel, Clarimon, Jordi, Zaman, Shahid H., Blesa, Rafael, Lleó, Alberto, Fortea, Juan
Format: Artigo
Language:Inglês
Published: American Medical Association 2021
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Original Investigation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8261691/
https://ncbi.nlm.nih.gov/pubmed/34228042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaneurol.2021.1893
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