Different roles for the acyl chain and the amine leaving group in the substrate selectivity of N-Acylethanolamine acid amidase

N-acylethanolamine acid amidase (NAAA) is an N-terminal nucleophile (Ntn) hydrolase that catalyses the intracellular deactivation of the endogenous analgesic and anti-inflammatory agent palmitoylethanolamide (PEA). NAAA inhibitors counteract this process and exert marked therapeutic effects in anima...

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Bibliografiske detaljer
Udgivet i:J Enzyme Inhib Med Chem
Main Authors: Ghidini, Andrea, Scalvini, Laura, Palese, Francesca, Lodola, Alessio, Mor, Marco, Piomelli, Daniele
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2021
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8279155/
https://ncbi.nlm.nih.gov/pubmed/34256657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2021.1912035
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