Paternal MTHFR deficiency leads to hypomethylation of young retrotransposons and reproductive decline across two successive generations

5,10-Methylenetetrahydrofolate reductase (MTHFR) is a crucial enzyme in the folate metabolic pathway with a key role in generating methyl groups. As MTHFR deficiency impacts male fertility and sperm DNA methylation, there is the potential for epimutations to be passed to the next generation. Here, w...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Development
Egile Nagusiak: Karahan, Gurbet, Chan, Donovan, Shirane, Kenjiro, McClatchie, Taylor, Janssen, Sanne, Baltz, Jay M., Lorincz, Matthew, Trasler, Jacquetta
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The Company of Biologists Ltd 2021
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8276981/
https://ncbi.nlm.nih.gov/pubmed/34128976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.199492
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