Alpha1-antitrypsin counteracts heme-induced endothelial cell inflammatory activation, autophagy dysfunction and death

Free heme toxicity in the vascular endothelium is critical for the pathogenesis of hemolytic disorders including sickle cell disease. In the current study, it is demonstrated that human alpha1-antitrypsin (A1AT), a serine protease inhibitor with high binding-affinity for heme, rescues endothelial ce...

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Detalles Bibliográficos
Publicado en:Redox Biol
Main Authors: Madyaningrana, Kukuh, Vijayan, Vijith, Nikolin, Christoph, Aljabri, Abid, Tumpara, Srinu, Korenbaum, Elena, Shah, Harshit, Stankov, Metodi, Fuchs, Heiko, Janciauskiene, Sabina, Immenschuh, Stephan
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2021
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8274343/
https://ncbi.nlm.nih.gov/pubmed/34246063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2021.102060
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