Alpha1-antitrypsin counteracts heme-induced endothelial cell inflammatory activation, autophagy dysfunction and death

Free heme toxicity in the vascular endothelium is critical for the pathogenesis of hemolytic disorders including sickle cell disease. In the current study, it is demonstrated that human alpha1-antitrypsin (A1AT), a serine protease inhibitor with high binding-affinity for heme, rescues endothelial ce...

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Vydáno v:Redox Biol
Hlavní autoři: Madyaningrana, Kukuh, Vijayan, Vijith, Nikolin, Christoph, Aljabri, Abid, Tumpara, Srinu, Korenbaum, Elena, Shah, Harshit, Stankov, Metodi, Fuchs, Heiko, Janciauskiene, Sabina, Immenschuh, Stephan
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2021
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8274343/
https://ncbi.nlm.nih.gov/pubmed/34246063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2021.102060
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