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TLR4 Signaling by Heme and the Role of Heme-Binding Blood Proteins

Toll-like receptors (TLRs), also known as pattern recognition receptors, respond to exogenous pathogens and to intrinsic danger signals released from damaged cells and tissues. The tetrapyrrole heme has been suggested to be an agonist for TLR4, the receptor for the pro-inflammatory bacterial compone...

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Detalhes bibliográficos
Main Authors: Sabina Janciauskiene, Vijith Vijayan, Stephan Immenschuh
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020-08-01
Colecção:Frontiers in Immunology
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Acesso em linha:https://www.frontiersin.org/article/10.3389/fimmu.2020.01964/full
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