PRPF19 regulates p53-dependent cellular senescence by modulating alternative splicing of MDM4 mRNA

Alteration of RNA splicing is a hallmark of cellular senescence, which is associated with age-related disease and cancer development. However, the roles of splicing factors in cellular senescence are not fully understood. In this study, we identified the splicing factor PRPF19 as a critical regulato...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Yano, Kimiyoshi, Takahashi, Ryou-u, Shiotani, Bunsyo, Abe, Junko, Shidooka, Tomoki, Sudo, Yuki, Yamamoto, Yusuke, Kan, Shisei, Sakagami, Hiroki, Tahara, Hidetoshi
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2021
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8274299/
https://ncbi.nlm.nih.gov/pubmed/34144037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100882
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