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Rational Control of Molecular Properties Is Mandatory to Exploit the Potential of PROTACs as Oral Drugs
[Image: see text] To obtain new oral drugs in the beyond rule of five space, PROTACs among others, molecular properties should be optimized in early drug discovery. Degraders call for design strategies which focus on intramolecular interaction and chameleonicity. In parallel, tailored revalidation o...
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| Yayımlandı: | ACS Med Chem Lett |
|---|---|
| Asıl Yazarlar: | , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
American Chemical
Society
2021
|
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8274089/ https://ncbi.nlm.nih.gov/pubmed/34262642 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.1c00298 |
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