Steering New Drug Discovery Campaigns: Permeability, Solubility, and Physicochemical Properties in the bRo5 Chemical Space

[Image: see text] An increasing number of drug discovery programs concern compounds in the beyond rule of 5 (bRo5) chemical space, such as cyclic peptides, macrocycles, and degraders. Recent results show that common paradigms of property-based drug design need revision to be applied to larger and mo...

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Bibliografiske detaljer
Udgivet i:ACS Med Chem Lett
Main Authors: Caron, Giulia, Kihlberg, Jan, Goetz, Gilles, Ratkova, Ekaterina, Poongavanam, Vasanthanathan, Ermondi, Giuseppe
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2021
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7812602/
https://ncbi.nlm.nih.gov/pubmed/33488959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00581
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