Caricamento...
Solution Conformations Shed Light on PROTAC Cell Permeability
[Image: see text] Proteolysis targeting chimeras (PROTACs) induce intracellular degradation of target proteins. Their bifunctional structure puts degraders in a chemical space where ADME properties often complicate drug discovery. Herein we provide the first structural insight into PROTAC cell perme...
Salvato in:
| Pubblicato in: | ACS Med Chem Lett |
|---|---|
| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Chemical Society
2020
|
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7812666/ https://ncbi.nlm.nih.gov/pubmed/33488971 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00556 |
| Tags: |
Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !
|