NudC L279P Mutation Destabilizes Filamin A by Inhibiting the Hsp90 Chaperoning Pathway and Suppresses Cell Migration

Filamin A, the first discovered non-muscle actin filament cross-linking protein, plays a crucial role in regulating cell migration that participates in diverse cellular and developmental processes. However, the regulatory mechanism of filamin A stability remains unclear. Here, we find that nuclear d...

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Udgivet i:Front Cell Dev Biol
Main Authors: Liu, Min, Xu, Zhangqi, Zhang, Cheng, Yang, Chunxia, Feng, Jiaxing, Lu, Yiqing, Zhang, Wen, Chen, Wenwen, Xu, Xiaoyang, Sun, Xiaoxia, Yang, Mingyang, Liu, Wei, Zhou, Tianhua, Yang, Yuehong
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021
Fag:
Cell and Developmental Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8273881/
https://ncbi.nlm.nih.gov/pubmed/34262899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2021.671233
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