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NudC-like protein 2 regulates the LIS1/dynein pathway by stabilizing LIS1 with Hsp90

The type I lissencephaly gene product LIS1, a key regulator of cytoplasmic dynein, is critical for cell proliferation, survival, and neuronal migration. However, little is known about the regulation of LIS1. Here, we identify a previously uncharacterized mammalian homolog of Aspergillus NudC, NudCL2...

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Detalhes bibliográficos
Main Authors: Yang, Yuehong, Yan, Xiaoyi, Cai, Yuqi, Lu, Yiqing, Si, Jianmin, Zhou, Tianhua
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2840461/
https://ncbi.nlm.nih.gov/pubmed/20133715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0914307107
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