A role for BDNF- and NMDAR-induced lysosomal recruitment of mTORC1 in the regulation of neuronal mTORC1 activity

Memory and long term potentiation require de novo protein synthesis. A key regulator of this process is mTORC1, a complex comprising the mTOR kinase. Growth factors activate mTORC1 via a pathway involving PI3-kinase, Akt, the TSC complex and the GTPase Rheb. In non-neuronal cells, translocation of m...

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Detalhes bibliográficos
Publicado no:Mol Brain
Main Authors: Khamsing, Dany, Lebrun, Solène, Fanget, Isabelle, Larochette, Nathanaël, Tourain, Christophe, de Sars, Vincent, Brunstein, Maia, Oheim, Martin, Carrel, Damien, Darchen, François, Desnos, Claire
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8273036/
https://ncbi.nlm.nih.gov/pubmed/34247625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13041-021-00820-8
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