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Loss of Flow Responsive Tie1 Results in Impaired Aortic Valve Remodeling

The mechanisms regulating endothelial cell response to hemodynamic forces required for heart valve development, especially valve remodeling, remain elusive. Tie1, an endothelial specific receptor tyrosine kinase, is up-regulated by oscillating shear stress and is required for lymphatic valve develop...

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Detalles Bibliográficos
Publicado en:Dev Biol
Autores principales: Qu, Xianghu, Violette, Kate, Sewell-Loftin, M. K., Soslow, Jonathan, Saint-Jean, LeShana, Hinton, Robert B., Merryman, W. David, Baldwin, H. Scott
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8269330/
https://ncbi.nlm.nih.gov/pubmed/31319059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2019.07.011
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