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Monosomy 3 Is Linked to Resistance to MEK Inhibitors in Uveal Melanoma

The use of MEK inhibitors in the therapy of uveal melanoma (UM) has been investigated widely but has failed to show benefits in clinical trials due to fast acquisition of resistance. In this study, we investigated a variety of therapeutic compounds in primary-derived uveal melanoma cell lines and fo...

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Detalles Bibliográficos
Publicado en:Int J Mol Sci
Main Authors: Mergener, Svenja, Siveke, Jens T., Peña-Llopis, Samuel
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2021
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8269285/
https://ncbi.nlm.nih.gov/pubmed/34201614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22136727
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