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Monosomy 3 Is Linked to Resistance to MEK Inhibitors in Uveal Melanoma

The use of MEK inhibitors in the therapy of uveal melanoma (UM) has been investigated widely but has failed to show benefits in clinical trials due to fast acquisition of resistance. In this study, we investigated a variety of therapeutic compounds in primary-derived uveal melanoma cell lines and fo...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Mergener, Svenja, Siveke, Jens T., Peña-Llopis, Samuel
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8269285/
https://ncbi.nlm.nih.gov/pubmed/34201614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22136727
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