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Potential of Telomerase in Age-Related Macular Degeneration—Involvement of Senescence, DNA Damage Response and Autophagy and a Key Role of PGC-1α

Age-related macular degeneration (AMD), the main cause of vision loss in the elderly, is associated with oxidation in the retina cells promoting telomere attrition. Activation of telomerase was reported to improve macular functions in AMD patients. The catalytic subunit of human telomerase (hTERT) m...

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Dettagli Bibliografici
Pubblicato in:Int J Mol Sci
Autori principali: Blasiak, Janusz, Szczepanska, Joanna, Fila, Michal, Pawlowska, Elzbieta, Kaarniranta, Kai
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2021
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8268995/
https://ncbi.nlm.nih.gov/pubmed/34281248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22137194
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