Cellular Senescence in Age-Related Macular Degeneration: Can Autophagy and DNA Damage Response Play a Role?

Age-related macular degeneration (AMD) is the main reason of blindness in developed countries. Aging is the main AMD risk factor. Oxidative stress, inflammation and some genetic factors play a role in AMD pathogenesis. AMD is associated with the degradation of retinal pigment epithelium (RPE) cells,...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Oxid Med Cell Longev
Main Authors: Blasiak, Janusz, Piechota, Malgorzata, Pawlowska, Elzbieta, Szatkowska, Magdalena, Sikora, Ewa, Kaarniranta, Kai
Format: Artigo
Jezik:Inglês
Izdano: Hindawi 2017
Teme:
Review Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5687149/
https://ncbi.nlm.nih.gov/pubmed/29225722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/5293258
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