From Genetics to Histomolecular Characterization: An Insight into Colorectal Carcinogenesis in Lynch Syndrome

Lynch syndrome is a hereditary cancer-predisposing syndrome caused by germline defects in DNA mismatch repair (MMR) genes such as MLH1, MSH2, MSH6, and PMS2. Carriers of pathogenic mutations in these genes have an increased lifetime risk of developing colorectal cancer (CRC) and other malignancies....

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Dades bibliogràfiques
Publicat a:Int J Mol Sci
Autors principals: Lepore Signorile, Martina, Disciglio, Vittoria, Di Carlo, Gabriella, Pisani, Antonio, Simone, Cristiano, Ingravallo, Giuseppe
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2021
Matèries:
Review
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8268977/
https://ncbi.nlm.nih.gov/pubmed/34201893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22136767
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