From Genetics to Histomolecular Characterization: An Insight into Colorectal Carcinogenesis in Lynch Syndrome

Lynch syndrome is a hereditary cancer-predisposing syndrome caused by germline defects in DNA mismatch repair (MMR) genes such as MLH1, MSH2, MSH6, and PMS2. Carriers of pathogenic mutations in these genes have an increased lifetime risk of developing colorectal cancer (CRC) and other malignancies....

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Lepore Signorile, Martina, Disciglio, Vittoria, Di Carlo, Gabriella, Pisani, Antonio, Simone, Cristiano, Ingravallo, Giuseppe
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
Assuntos:
Review
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8268977/
https://ncbi.nlm.nih.gov/pubmed/34201893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22136767
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