Pharmacological targeting of the novel β-catenin chromatin-associated kinase p38α in colorectal cancer stem cell tumorspheres and organoids

The prognosis of locally advanced colorectal cancer (CRC) is currently unsatisfactory. This is mainly due to drug resistance, recurrence, and subsequent metastatic dissemination, which are sustained by the cancer stem cell (CSC) population. The main driver of the CSC gene expression program is Wnt s...

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Publicado en:Cell Death Dis
Main Authors: Lepore Signorile, Martina, Grossi, Valentina, Di Franco, Simone, Forte, Giovanna, Disciglio, Vittoria, Fasano, Candida, Sanese, Paola, De Marco, Katia, Susca, Francesco Claudio, Mangiapane, Laura Rosa, Nicotra, Annalisa, Di Carlo, Gabriella, Dituri, Francesco, Giannelli, Gianluigi, Ingravallo, Giuseppe, Canettieri, Gianluca, Stassi, Giorgio, Simone, Cristiano
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2021
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7994846/
https://ncbi.nlm.nih.gov/pubmed/33767160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-021-03572-4
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