Pharmacological targeting of the novel β-catenin chromatin-associated kinase p38α in colorectal cancer stem cell tumorspheres and organoids

The prognosis of locally advanced colorectal cancer (CRC) is currently unsatisfactory. This is mainly due to drug resistance, recurrence, and subsequent metastatic dissemination, which are sustained by the cancer stem cell (CSC) population. The main driver of the CSC gene expression program is Wnt s...

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Publicat a:Cell Death Dis
Autors principals: Lepore Signorile, Martina, Grossi, Valentina, Di Franco, Simone, Forte, Giovanna, Disciglio, Vittoria, Fasano, Candida, Sanese, Paola, De Marco, Katia, Susca, Francesco Claudio, Mangiapane, Laura Rosa, Nicotra, Annalisa, Di Carlo, Gabriella, Dituri, Francesco, Giannelli, Gianluigi, Ingravallo, Giuseppe, Canettieri, Gianluca, Stassi, Giorgio, Simone, Cristiano
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7994846/
https://ncbi.nlm.nih.gov/pubmed/33767160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-021-03572-4
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