Knockout of Putative Tumor Suppressor Aldh1l1 in Mice Reprograms Metabolism to Accelerate Growth of Tumors in a Diethylnitrosamine (DEN) Model of Liver Carcinogenesis

SIMPLE SUMMARY: Cancers often loose the enzyme of folate metabolism ALDH1L1. We proposed that such loss is advantageous for the malignant tumor growth and tested this hypothesis in mice proficient or deficient (gene knockout) in ALDH1L1 expression. Liver cancer in both groups was induced by injectio...

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Publicat a:Cancers (Basel)
Autors principals: Krupenko, Natalia I., Sharma, Jaspreet, Fogle, Halle M., Pediaditakis, Peter, Strickland, Kyle C., Du, Xiuxia, Helke, Kristi L., Sumner, Susan, Krupenko, Sergey A.
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8268287/
https://ncbi.nlm.nih.gov/pubmed/34203215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers13133219
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