Differential Expression of One‐Carbon Pathway Enzyme ALDH1L1 Is Linked to Tumorigenicity of Low‐Grade Bladder Cancer Cells Through Metabolic Reprogramming

ABSTRACT Background RT4 bladder cancer cell line, derived from a nonmuscle‐invasive low‐grade subtype, is one of the few neoplastic cell lineages that maintain high expression of the candidate tumor suppressor ALDH1L1. Here, we investigated how differential ALDH1L1 expression affects cellular charac...

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Principais autores:	Halle M. Meyers, Jaspreet Sharma, Amira A. Abdellatef, Mikyoung You, David Raines, Kyle C. Strickland, Susan Sumner, Blake R. Rushing, Natalia I. Krupenko, Sergey A. Krupenko
Formato:	Artigo
Idioma:	Inglês
Publicado:	Wiley 2025-10-01
Series:	Cancer Medicine
Assuntos:	ALDH1L1 one‐carbon metabolism RT4 bladder cancer cells untargeted metabolomics xenograft tumors
Acceso en liña:	https://doi.org/10.1002/cam4.71291
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