Bintrafusp Alfa, a Bifunctional Fusion Protein Targeting TGF-β and PD-L1, in Patients with Esophageal Adenocarcinoma: Results from a Phase 1 Cohort

BACKGROUND: Esophageal adenocarcinoma patients have limited treatment options. TGF-β can be upregulated in esophageal adenocarcinoma, and blocking this pathway may enhance clinical response to PD-(L)1 inhibitors. Bintrafusp alfa is a first-in-class bifunctional fusion protein composed of the extrace...

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Detalhes bibliográficos
Publicado no:Target Oncol
Main Authors: Tan, Benjamin, Khattak, Adnan, Felip, Enriqueta, Kelly, Karen, Rich, Patricia, Wang, Ding, Helwig, Christoph, Dussault, Isabelle, Ojalvo, Laureen S., Isambert, Nicolas
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2021
Assuntos:
Original Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8266790/
https://ncbi.nlm.nih.gov/pubmed/34009501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11523-021-00809-2
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