Selection of the Recommended Phase 2 Dose for Bintrafusp Alfa, a Bifunctional Fusion Protein Targeting TGF‐β and PD‐L1

Bintrafusp alfa, a first‐in‐class bifunctional fusion protein composed of the extracellular domain of the TGF‐βRII receptor (TGF‐β “trap”) fused to a human IgG1‐blocking PD‐L1, showed a manageable safety profile and clinical activity in phase I studies in patients with heavily pretreated advanced so...

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Detalhes bibliográficos
Publicado no:Clin Pharmacol Ther
Main Authors: Vugmeyster, Yulia, Wilkins, Justin, Koenig, Andre, El Bawab, Samer, Dussault, Isabelle, Ojalvo, Laureen S., De Banerjee, Samrita, Klopp‐Schulze, Lena, Khandelwal, Akash
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7484916/
https://ncbi.nlm.nih.gov/pubmed/31955412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.1776
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