Bintrafusp alfa, a bifunctional fusion protein targeting TGF-β and PD-L1, in patients with human papillomavirus-associated malignancies

BACKGROUND: Bintrafusp alfa is a first-in-class bifunctional fusion protein composed of the extracellular domain of transforming growth factor (TGF)-βRII (a TGF-β ‘trap’) fused to a human IgG1 mAb blocking programmed cell death ligand 1. This is the largest analysis of patients with advanced, pretre...

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Опубликовано в: :J Immunother Cancer
Главные авторы: Strauss, Julius, Gatti-Mays, Margaret E, Cho, Byoung Chul, Hill, Andrew, Salas, Sébastien, McClay, Edward, Redman, Jason M, Sater, Houssein A, Donahue, Renee N, Jochems, Caroline, Lamping, Elizabeth, Burmeister, Andrea, Marté, Jennifer L, Cordes, Lisa M, Bilusic, Marijo, Karzai, Fatima, Ojalvo, Laureen S, Jehl, Genevieve, Rolfe, P Alexander, Hinrichs, Christian S, Madan, Ravi A, Schlom, Jeffrey, Gulley, James L
Формат: Artigo
Язык:Inglês
Опубликовано: BMJ Publishing Group 2020
Предметы:
Clinical/Translational Cancer Immunotherapy
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7745517/
https://ncbi.nlm.nih.gov/pubmed/33323462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-001395
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