Bintrafusp alfa, a bifunctional fusion protein targeting TGF-β and PD-L1, in advanced squamous cell carcinoma of the head and neck: results from a phase I cohort

BACKGROUND: We report the clinical activity and safety of bintrafusp alfa, a first-in-class bifunctional fusion protein composed of the extracellular domain of the transforming growth factor β (TGF-β)RII receptor (a TGF-β ‘trap’) fused to a human IgG1 monoclonal antibody blocking programmed death-li...

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Vydáno v:J Immunother Cancer
Hlavní autoři: Cho, Byoung Chul, Daste, Amaury, Ravaud, Alain, Salas, Sébastien, Isambert, Nicolas, McClay, Edward, Awada, Ahmad, Borel, Christian, Ojalvo, Laureen S, Helwig, Christoph, Rolfe, P Alexander, Gulley, James L, Penel, Nicolas
Médium: Artigo
Jazyk:Inglês
Vydáno: BMJ Publishing Group 2020
Témata:
Clinical/Translational Cancer Immunotherapy
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7342865/
https://ncbi.nlm.nih.gov/pubmed/32641320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-000664
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